Poze Tablets Specification

Requires Prescription (YES/NO)

Yes

Generics

Pioglitazone HCl

Used For

Diabetes

How it works

Pioglitazone is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. Pioglitazone decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferator-activated receptor-gamma (PPAR?). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR? nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism.

Poze Tablets Usage And Safety

Dosage

Pioglitazone HCl

Side Effects

Very Common : Hypoglycaemia, edema.Common : Visual disturbances, upper respiratory tract infection, weight increase, hypoaesthesia, anemia, arthralgia, headache, haematuria, erectile dysfunction, flatulence, dizziness, blood creatine phosphokinase increase, bronchitis, back pain, dyspnoea, heart failure.Rare : Sinusitis, flatulence, vertigo, fatigue, increased lactic dehydrogenase, appetite increased, hypoglycaemia, headache, glycosuria, proteinuria, sweating.

Drug Interactions

Midazolam , Gemfibrozil , Rifampicin.

Indication

It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

When not to Use

Pioglitazone is contraindicated in patients with: • Hypersensitivity to the active substance or to any of the excipients. • Cardiac failure or history of cardiac failure (NYHA stages I to IV). • Hepatic impairment • Diabetic ketoacidosis.

Poze Tablets Precautions

Precaution

Pioglitazone exerts its antihyperglycemic effect only in the presence of insulin. Therefore, pioglitazone should not be used in patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.

Poze Tablets Warnings

Warning 1

Patients receiving pioglitazone in combination with insulin or oral hypoglycemic agents may be at risk for hypoglycemia, and a reduction in the dose of the concomitant agent may be necessary.

Warning 2

Pioglitazone may cause decreases in hemoglobin and hematocrit.

Warning 3

Dose related weight gain may occur with pioglitazone alone and in combination with other hypoglycemic agents.

Poze Tablets Additional Information

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.