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Sale Co-aprovel Tablets 150-12.5mg

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Sanofi-Aventis Pakistan Ltd

Co-aprovel Tablets 150-12.5mg

4.7 · 48 customer reviews
In stock Per Strip
Rs 887 Rs 843 Save Rs 44 (5% off)

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Customer reviews

  • Ali N. 25-May-2025 || 06:57 AM

    Smooth ordering process for co-aprovel tablets 150-12.5mg. Email confirmation and dispatch SMS were helpful.

  • Fatima R. 08-Nov-2025 || 12:07 AM

    Good deal on co-aprovel tablets 150-12.5mg during sale. Still authentic — checked barcode.

  • Sadia A. 24-Apr-2026 || 08:17 AM

    Good for repeat purchases. co-aprovel tablets 150-12.5mg stock was available when other sites were out.

  • Sadia N. 10-Apr-2026 || 01:08 AM

    Trust factor is high for co-aprovel tablets 150-12.5mg here. Proper GST-style receipt provided.

  • Zainab A. 15-Dec-2025 || 09:19 AM

    Reliable source for co-aprovel tablets 150-12.5mg in Pakistan. Invoice helped for office reimbursement.

  • Hira S. 09-Jun-2025 || 04:28 AM

    Quick response when I asked about substitutes for co-aprovel tablets 150-12.5mg. Good pharmacy ethics.

  • Omar S. 31-Jan-2026 || 07:53 AM

    Satisfied with co-aprovel tablets 150-12.5mg for home use. Website is easy on mobile too.

  • Ali J. 29-Dec-2025 || 02:07 AM

    Reasonable delivery fee for co-aprovel tablets 150-12.5mg to Karachi. Product exactly as shown online.

  • Fatima N. 18-May-2026 || 05:13 AM

    Impressed with how co-aprovel tablets 150-12.5mg was bubble-wrapped. Cold chain not needed but pack was solid.

  • Hassan T. 17-Jan-2025 || 04:12 AM

    Second time buying co-aprovel tablets 150-12.5mg — same quality as first order. Loyal customer now.

  • Saad N. 14-Nov-2025 || 03:53 AM

    Minor delay for co-aprovel tablets 150-12.5mg due to rain in Hyderabad, but team kept me updated.

  • Hira R. 13-Feb-2026 || 01:56 AM

    Happy with co-aprovel tablets 150-12.5mg. Customer team confirmed batch details before dispatch. Professional service.

  • Waqas K. 07-May-2025 || 11:19 PM

    Clear product page for co-aprovel tablets 150-12.5mg helped me compare strength and pack size.

  • Rabia N. 07-Jun-2025 || 10:57 PM

    Good experience overall. co-aprovel tablets 150-12.5mg price beat the market near Sialkot.

  • Faisal Q. 04-Jul-2025 || 12:46 AM

    No complaints about co-aprovel tablets 150-12.5mg. Would suggest adding more payment options, otherwise great.

  • Omar Q. 18-Oct-2025 || 01:50 AM

    Fair pricing on co-aprovel tablets 150-12.5mg compared to other online stores in Pakistan. No hidden charges.

  • Faisal A. 26-Jul-2025 || 12:20 AM

    My pharmacist confirmed co-aprovel tablets 150-12.5mg looked original. MedicinePrices.pk is now my go-to.

  • Noman A. 22-May-2025 || 09:43 AM

    Bulk-friendly service; I ordered several units of co-aprovel tablets 150-12.5mg without hassle.

  • Usman R. 01-Jan-2025 || 11:26 PM

    Asked questions about co-aprovel tablets 150-12.5mg on WhatsApp — got a clear reply within minutes.

  • Kashif R. 26-Dec-2024 || 06:51 AM

    Took co-aprovel tablets 150-12.5mg as directed — improvement as expected. Thanks for timely supply to Peshawar.

  • Bilal I. 13-Apr-2025 || 02:58 AM

    Genuine co-aprovel tablets 150-12.5mg — sealed pack and correct expiry. Delivered within 2 days in Lahore.

  • Saad Q. 06-Jan-2026 || 12:26 AM

    Good experience with co-aprovel tablets 150-12.5mg. Price was better than local pharmacy and delivery was on time.

  • Kamran Q. 30-Jul-2025 || 06:21 AM

    Received co-aprovel tablets 150-12.5mg in good condition. Tracking updates were accurate. Five stars.

  • Faisal Q. 16-Mar-2026 || 02:59 AM

    Using co-aprovel tablets 150-12.5mg for two weeks — no side issues from supply. Seems genuine.

  • Usman N. 21-Nov-2025 || 01:56 AM

    Happy that co-aprovel tablets 150-12.5mg is sourced properly. Feels like a real licensed pharmacy operation.

  • Shahid A. 09-Oct-2025 || 10:02 PM

    Using co-aprovel tablets 150-12.5mg as prescribed — no issues with quality. Will order again from MedicinePrices.pk.

  • Kashif N. 30-Jun-2025 || 12:14 AM

    Recommended co-aprovel tablets 150-12.5mg to a colleague — they also had a positive experience.

  • Tariq Q. 29-Jul-2025 || 03:05 AM

    Been ordering co-aprovel tablets 150-12.5mg monthly. Never received a damaged or near-expiry pack so far.

  • Kamran B. 22-Mar-2026 || 11:26 PM

    Will continue co-aprovel tablets 150-12.5mg from this store — consistent batches and polite support.

  • Faisal K. 05-May-2026 || 05:59 AM

    Checked co-aprovel tablets 150-12.5mg with local chemist — said supply looks fine. Relief!

  • Sadia K. 11-Oct-2025 || 02:08 AM

    Excellent communication about co-aprovel tablets 150-12.5mg availability. No fake “in stock” trap.

  • Hira J. 30-Sep-2025 || 05:53 AM

    Quality of co-aprovel tablets 150-12.5mg is as expected. Instructions on label were clear. Trustworthy site.

  • Saad R. 21-May-2026 || 09:04 AM

    Ordered co-aprovel tablets 150-12.5mg with other items — all packed in one box, nothing missing.

  • Hassan B. 05-Jan-2026 || 10:40 PM

    Fast delivery of co-aprovel tablets 150-12.5mg to Quetta. Packaging was secure and invoice was included.

  • Bilal Q. 09-May-2025 || 10:38 PM

    Simple reorder of co-aprovel tablets 150-12.5mg from order history would be nice — product itself is great.

  • Kamran T. 11-Dec-2025 || 11:14 PM

    Packaging of co-aprovel tablets 150-12.5mg was discreet and professional. Delivery agent called before arrival.

  • Noman N. 28-Feb-2026 || 12:24 AM

    Helpful staff guided me on dosage for co-aprovel tablets 150-12.5mg. Extra care appreciated.

  • Hassan T. 05-May-2026 || 08:16 AM

    Five-star for co-aprovel tablets 150-12.5mg quality; four-star only because I wanted Sunday delivery.

  • Hira K. 21-May-2026 || 10:29 PM

    Found co-aprovel tablets 150-12.5mg after searching many sites. MedicinePrices.pk had real stock.

  • Usman I. 10-Oct-2025 || 06:31 AM

    co-aprovel tablets 150-12.5mg arrived before the estimated date in Lahore. Legit pharmacy feel, not a random seller.

  • Kamran R. 07-Jul-2025 || 08:01 AM

    Bought co-aprovel tablets 150-12.5mg twice now — consistent quality and reliable courier each time.

  • Fatima I. 22-Nov-2025 || 05:31 AM

    First order of co-aprovel tablets 150-12.5mg went smoothly. COD worked fine and rider was polite.

  • Omar M. 09-Mar-2025 || 07:14 AM

    Recommended by my doctor; found co-aprovel tablets 150-12.5mg here at a fair price. Checkout was simple.

  • Kamran J. 10-May-2025 || 09:33 AM

    Ordered co-aprovel tablets 150-12.5mg for my parents. MedicinePrices.pk verified stock and helpful WhatsApp support.

  • Hina B. 13-Feb-2026 || 08:18 AM

    Needed co-aprovel tablets 150-12.5mg urgently — team arranged quick dispatch. Product was original MRP labeled.

  • Waqas N. 11-Feb-2026 || 04:30 AM

    Value for money on co-aprovel tablets 150-12.5mg. Discount was applied correctly at checkout.

  • Sadia T. 22-Jun-2025 || 03:18 AM

    Received correct quantity of co-aprovel tablets 150-12.5mg. Strip seal was intact. Happy with the purchase.

  • Ali N. 11-Jun-2026 || 06:40 AM

    Authentic product. co-aprovel tablets 150-12.5mg matched the description on the website. Satisfied customer.

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Description

Co-Aprovel Tablets Specification

Requires Prescription (YES/NO)

Yes

Generics

 Irbesartan , Hydrochlorothiazide

Used For

Hypertension

How it works

Irbesartan : Irbesartan is a potent, orally active, selective angiotensin-II receptor (type AT1) antagonist. It is expected to block all actions of angiotensin-II mediated by the AT1 receptor, regardless of the source or route of synthesis of angiotensin-II. The selective antagonism of the angiotensin-II (AT1) receptors results in increases in plasma renin levels and angiotensin-II levels, and a decrease in plasma aldosterone concentration. Serum potassium levels are not significantly affected by irbesartan alone at the recommended doses. Irbesartan does not inhibit ACE (kininase-II), an enzyme which generates angiotensin-II and also degrades bradykinin into inactive metabolites. Irbesartan does not require metabolic activation for its activity. Hydrochlorothiazide : Hydrochlorothiazide is a thiazide diuretic. The mechanism of antihypertensive effect of thiazide diuretic is not fully known. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. The diuretic action of hydrochlorothiazide reduces plasma volume, increases plasma renin activity, increases aldosterone secretion, with consequent increases in urinary potassium and bicarbonate loss, and decreases in serum potassium. Presumably through blockade of the renin-angiotensin-aldosterone system, co-administration of irbesartan tends to reverse the potassium loss associated with these diuretics. With hydrochlorothiazide, onset of diuresis occurs in 2 hours, and peak effect occurs at about 4 hours, while the action persists for approximately 6-12 hours.

Co-Aprovel Tablets Usage And Safety

Dosage

 Irbesartan , Hydrochlorothiazide

Side Effects

Cardiac disorders: Common: increases in blood urea nitrogen (BUN), creatinine and creatine kinase Uncommon: decreases in serum potassium and sodium .Uncommon: syncope, hypotension, tachycardia, oedema.Nervous system disorders: Common: dizziness Uncommon: orthostatic dizziness Not known: headache . Ear and labyrinth disorders: Not known: tinnitus. Respiratory, thoracic and mediastinal disorders: Not known: cough. Gastrointestinal disorders: Common: nausea/vomiting , Uncommon: diarrhoea , Not known: dyspepsia, dysgeusia .

Drug Interactions

Irbesartan : Lithium , kaliuretic diuretics, laxatives, amphotericin, carbenoxolone, penicillin G sodium , heparin sodium , digitalis glycosides, antiarrhythmics , selective COX-2 inhibitors, acetylsalicylic acid , Hydrochlorothiazide: Thiazide diuretics , Alcohol , Antidiabetic medicinal products (oral agents and insulins) , Colestyramine and Colestipol resins , Corticosteroids, ACTH , Digitalis glycoside , Pressor amines (e.g. noradrenaline) , tubocurarine , probenecid or sulfinpyrazone , calcium supplements or calcium sparing medicinal products (e.g. vitamin D therapy) , Carbamazepine , atropine, beperiden , cyclophosphamide, methotrexate.

Indication

• Treatment of essential hypertension. • This fixed dose combination is indicated in adult patients whose blood pressure is not adequately controlled on irbesartan or hydrochlorothiazide alone. • It may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals .

When not to Use

• Hypersensitivity to the active substances or to any of the excipients or to other sulfonamide-derived substances (hydrochlorothiazide is a sulfonamide-derived substance)• Second and third trimesters of pregnancy.• Severe renal impairment (creatinine clearance <30 ml/min).• Refractory hypokalaemia, hypercalcaemia.• Severe hepatic impairment, biliary cirrhosis and cholestasis.• The concomitant use of Irbesartan/Hydrochlorothiazide with aliskiren-containing products is contraindicated in patients with diabetes mellitus or renal impairment (creatinine clearance <60ml/min/1.73 m²).• Due to its HCT component Irbesartan/HCT tablets are contraindicated in anuric patients

Co-Aprovel Tablets Precautions

Precaution

It has been rarely associated with symptomatic hypotension in hypertensive patients without other risk factors for hypotension. Symptomatic hypotension may be expected to occur in patients who are volume and/or sodium depleted by vigorous diuretic therapy, dietary salt restriction, diarrhea or vomiting. Such conditions should be corrected before initiating therapy with Irbesartan/Hydrochlorothiazide.

Co-Aprovel Tablets Warnings

Warning 1

There is an increased risk of severe hypotension and renal insufficiency when patients with bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated with angiotensin converting enzyme inhibitors or angiotensin-II receptor antagonists. While this is not documented with Irbesartan/Hydrochlorothiazide , a similar effect should be anticipated.

Warning 2

Patients with primary aldosteronism generally will not respond to antihypertensive medicinal products acting through inhibition of the renin-angiotensin system. Therefore, the use of Irbesartan/Hydrochlorothiazide is not recommended.

Warning 3

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma. Irbesartan/HCT must not be used in patients with severe hepatic impairment. No dosage adjustment is required in patients with mild to moderate hepatic impairment.

Co-Aprovel Tablets Additional Information

Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.

Product information
Unit
Per Strip
SKU
#247

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